The incidence of BSE cases in cattle has declined, but the risk of contracting the human form of BSE, vCJD, remains a serious threat. In addition to eating contaminated beef, the disease can be also transmitted from one human being to another through organ and tissue transplantations and blood transfusions. The latter harbors an extreme potential risk, since blood from one donor can infect multiple receivers. Recent research has demonstrated that sensitive detection of prions in blood is possible. Using a combination of Prionics antibody 15B3 and prion amplification, the blood test is 10,000 times more sensitive than previously reported assays.